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Lecture: Lecture: Chromatographic Separation Processes - Details
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Course name Lecture: Lecture: Chromatographic Separation Processes
Subtitle Module: Separation Technologies for Life Sciences
Course number 17941_W18
Semester WiSe 18/19
Current number of participants 54
Home institute Institut für Thermische Verfahrenstechnik (V-8)
Courses type Lecture in category Teaching
First date Fri., 19.10.2018 09:45 - 13:00
Pre-requisites Fundamentals of Chemistry, Fluid Process Engineering, Thermal Separation Processes, Chemical Engineering, Chemical Engineering, Bioprocess Engineering
Basic knowledge in thermodynamics and in unit operations related to thermal separation processes
Performance record Written exam
ECTS points 2

Course location / Course dates

(D 1.023) Friday: 09:45 - 13:00, fortnightly (5x)
n.a. Friday: 09:45 - 13:00, fortnightly


- Introduction: overview, history of chromatography, LC (HPLC), GC, SFC
- Fundamentals of linear (analytical) chromatography, retention time/factor, separation factor, peak resolution, band broadening, Van-Deemter equation
- Fundamentals of nonlinear chromatography, discontinuous and continuous preparative chromatography (annular, true moving bed - TMB, simulated moving bed - SMB)
- Adsorption equilibrium: experimental determination of adsorption isotherms and modeling

- Equipment for chromatography, production and characterization of chromatographic adsorbents
- Method development, scale up methods, process design, modeling of chromatographic processes, economic aspects
- Applications: e.g. normal phase chromatography, reversed phase chromatography, hydrophobic interaction chromatography, chiral chromatography, bioaffinity chromatography, ion exchange chromatography

- Schmidt-Traub, H.: Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents. Weinheim: Wiley-VCH (2005) - eBook
- Carta, G.: Protein chromatography: process development and scale-up. Weinheim: Wiley-VCH (2010)
- Guiochon, G.; Lin, B.: Modeling for Preparative Chromatography. Amsterdam: Elsevier (2003)
- Hagel, L.: Handbook of process chromatography: development, manufacturing, validation and economics. London ;Burlington, MA Academic (2008) - eBook

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